Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Candida albicans, along with other closely related Candida species, are the primary
causative agents of vulvovaginal candidiasis (VVC)—a multifactorial infectious disease of …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Patients with suppressed immunity are at the highest risk for hospital-acquired infections.
Among these, invasive candidiasis is the most prevalent systemic fungal nosocomial …

The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal …

Clearance of invading microbes requires phagocytes of the innate immune system.
However, successful pathogens have evolved sophisticated strategies to evade immune …

Although a number of fungal species belonging to the genus C andida can cause acute
vulvovaginal infection (VVC), C andida albicans is by far the most prevalent etiological …

The intestinal microbiota comprises diverse fungal and viral components, in addition to
bacteria. These microbes interact with the immune system and affect human physiology …

Highlights•The cell biology of Candida albicans is adapted both for life as a commensal and
as a pathogen.•C. albicans can either downregulate or upregulate virulence properties in …

The host type I interferon (IFN) pathway is a major signature of inflammation induced by the
human fungal pathogen, Candida albicans. However, the molecular mechanism for …