Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Revolutionizing medicinal chemistry: the application of artificial intelligence (AI) in early drug discovery
Artificial intelligence (AI) has permeated various sectors, including the pharmaceutical
industry and research, where it has been utilized to efficiently identify new chemical entities …
industry and research, where it has been utilized to efficiently identify new chemical entities …
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy
The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
Disorder-to-order transition of the amyloid-β peptide upon lipid binding
There is mounting evidence that Alzheimer's disease progression and severity are linked to
neuronal membrane damage caused by aggregates of the amyloid-β (A β) peptide …
neuronal membrane damage caused by aggregates of the amyloid-β (A β) peptide …
Spike Protein Fragments Promote Alzheimer's Amyloidogenesis
Alzheimer's disease (AD) is a major cause of dementia inducing memory loss, cognitive
decline, and mortality among the aging population. While the amyloid aggregation of …
decline, and mortality among the aging population. While the amyloid aggregation of …
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone
C Zhang, Y Pei, Z Zhang, L Xu, X Liu, L Jiang… - Communications …, 2022 - nature.com
Abstract α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …
Amyloid aggregates exert cell toxicity causing irreversible damages in the endoplasmic reticulum
Amyloid oligomers and fibrils are protein aggregates that cause an onset and progression of
many neurodegenerative diseases, diabetes type 2 and systemic amyloidosis. Although a …
many neurodegenerative diseases, diabetes type 2 and systemic amyloidosis. Although a …
Imaging Amyloid‐β Membrane Interactions: Ion‐Channel Pores and Lipid‐Bilayer Permeability in Alzheimer's Disease
JH Viles - Angewandte Chemie International Edition, 2023 - Wiley Online Library
The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …
Free gangliosides can alter amyloid-β aggregation
A recently proposed lipid-chaperone hypothesis suggests that free lipid molecules, not
bound to membranes, affect the aggregation of amyloidogenic peptides such as amyloid-β …
bound to membranes, affect the aggregation of amyloidogenic peptides such as amyloid-β …