Nanotechnology applications for improved delivery of antiretroviral drugs to the brain
Human immunodeficiency virus (HIV) can gain access to the central nervous system during
the early course of primary infection. Once in the brain compartment the virus actively …
the early course of primary infection. Once in the brain compartment the virus actively …
Cell penetrating peptides in the delivery of biopharmaceuticals
The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules
including DNA, oligonucleotides, peptides and proteins used as therapeutic agents …
including DNA, oligonucleotides, peptides and proteins used as therapeutic agents …
An update on pharmaceutical strategies for oral delivery of therapeutic peptides and proteins in adults and pediatrics
While each route of therapeutic drug delivery has its own advantages and limitations, oral
delivery is often favored because it offers convenient painless administration, sustained …
delivery is often favored because it offers convenient painless administration, sustained …
Therapeutic potential of cell-penetrating peptides
The ability of cell-penetrating peptides to cross plasma membranes has been used for
various applications, including the delivery of bioactive molecules to inhibit disease …
various applications, including the delivery of bioactive molecules to inhibit disease …
Design, synthesis and characterization of a new anionic cell‐penetrating peptide: SAP (E)
I Martín, M Teixidó, E Giralt - ChemBioChem, 2011 - Wiley Online Library
Cell‐penetrating peptides (CPPs) are powerful tools to transport cell‐impermeable cargoes
into the cytoplasm without damaging the cell membrane. The vast majority of these peptides …
into the cytoplasm without damaging the cell membrane. The vast majority of these peptides …
Antisense peptide nucleic acid–diaminobutanoic acid dendron conjugates with sbma-independent antimicrobial activity against gram-negative bacteria
Precision antisense antibacterial agents may be developed into novel antibiotics in the fight
against multidrug-resistant Gram-negative bacteria. In this study, a series of …
against multidrug-resistant Gram-negative bacteria. In this study, a series of …
Is there a future for cell-penetrating peptides in oligonucleotide delivery?
Cell-penetrating peptides have been widely investigated as delivery vehicles for
oligonucleotides (eg, siRNA and antisense oligonucleotides). Different delivery strategies …
oligonucleotides (eg, siRNA and antisense oligonucleotides). Different delivery strategies …
Prediction of cell-penetrating potential of modified peptides containing natural and chemically modified residues
Designing drug delivery vehicles using cell-penetrating peptides is a hot area of research in
the field of medicine. In the past, number of in silico methods have been developed for …
the field of medicine. In the past, number of in silico methods have been developed for …
Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids
Sequence-selective recognition of complex RNAs in live cells could find broad applications
in biology, biomedical research, and biotechnology. However, specific recognition of …
in biology, biomedical research, and biotechnology. However, specific recognition of …
Preclinical Pharmacokinetics in Tumors and Normal Tissues of the Antigene PNA Oligonucleotide MYCN-Inhibitor BGA002
AL Scardovi, D Bartolucci, L Montemurro… - nucleic acid …, 2024 - liebertpub.com
Although MYCN has been considered an undruggable target, MYCN alterations confer poor
prognosis in many pediatric and adult cancers. The novel MYCN-specific inhibitor BGA002 …
prognosis in many pediatric and adult cancers. The novel MYCN-specific inhibitor BGA002 …