[HTML][HTML] Global pandemics interconnected—obesity, impaired metabolic health and COVID-19
Obesity and impaired metabolic health are established risk factors for the non-
communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease …
communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study
X Chen, X Hong, W Gao, S Luo, J Cai, G Liu… - Journal of translational …, 2022 - Springer
Background The 2019 coronavirus disease pandemic (COVID-19) poses an enormous
threat to public health worldwide, and the ensuing management of social isolation has …
threat to public health worldwide, and the ensuing management of social isolation has …
[HTML][HTML] Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort
Background Conflicting evidence has emerged regarding the relevance of smoking on risk
of COVID-19 and its severity. Methods We undertook large-scale observational and …
of COVID-19 and its severity. Methods We undertook large-scale observational and …
Cardiometabolic risk factors for COVID-19 susceptibility and severity: a Mendelian randomization analysis
Background Epidemiological studies report associations of diverse cardiometabolic
conditions including obesity with COVID-19 illness, but causality has not been established …
conditions including obesity with COVID-19 illness, but causality has not been established …
Mendelian randomization analysis reveals no causal relationship between nonalcoholic fatty liver disease and severe COVID-19
J Li, A Tian, H Zhu, L Chen, J Wen, W Liu… - Clinical Gastroenterology …, 2022 - Elsevier
Background & Aims The coronavirus disease 2019 (COVID-19) pandemic has witnessed
more than 4.5 million deaths as of the time of writing. Whether nonalcoholic fatty liver …
more than 4.5 million deaths as of the time of writing. Whether nonalcoholic fatty liver …
Association of genetically predicted insomnia with risk of sepsis: a mendelian randomization study
MS Thorkildsen, LT Gustad, RM Mohus… - JAMA …, 2023 - jamanetwork.com
Importance Insomnia has been associated with altered inflammatory response as well as
increased risk of infections and sepsis in observational studies. However, these studies are …
increased risk of infections and sepsis in observational studies. However, these studies are …
Causal effects of gut microbiota on sepsis: a two-sample Mendelian randomization study
JH Chen, LY Zeng, YF Zhao, HX Tang, H Lei… - Frontiers in …, 2023 - frontiersin.org
Background Recent studies had provided evidence that the gut microbiota is associated with
sepsis. However, the potential causal relationship remained unclear. Methods The present …
sepsis. However, the potential causal relationship remained unclear. Methods The present …
[HTML][HTML] Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study
Objectives Recent studies suggested obesity to be a possible risk factor for COVID-19
disease in the wake of the coronavirus (SARS-CoV-2) infection. However, the causality and …
disease in the wake of the coronavirus (SARS-CoV-2) infection. However, the causality and …
A research agenda for precision medicine in sepsis and acute respiratory distress syndrome: an official American Thoracic Society research statement
Background: Precision medicine focuses on the identification of therapeutic strategies that
are effective for a group of patients based on similar unifying characteristics. The recent …
are effective for a group of patients based on similar unifying characteristics. The recent …