Allosteric regulation is a common mechanism employed by complex biomolecular systems
for regulation of activity and adaptability in the cellular environment, serving as an effective …

Protein–protein interactions (PPIs) occur in complex networks. These networks are highly
dependent on cellular context and can be extensively altered in disease states such as …

Allosteric drugs have been attracting increasing interest over the past few years. In this
context, it is common practice to use high-throughput screening for the discovery of non …

Molecular chaperones, a family of proteins of which Hsp90 and Hsp70 are integral
members, form an essential machinery to maintain healthy proteomes by controlling the …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

Colorectal cancer (CRC) is one of the most common malignancies in the world. Despite
intensive advances in diagnosis and treatment of CRC, it is yet one of the leading cause of …

The molecular chaperones Hsp90 and Hsp70 and their regulatory co-chaperone Hop play a
key role at the crossroads of the folding pathways of numerous client proteins by forming fine …

Non-coding RNAs (ncRNAs), generated from nonprotein coding DNA sequences, constitute
98–99% of the human genome. Non-coding RNAs encompass diverse functional classes …

The potential of small molecules to localize within subcellular compartments is rarely
explored. To probe this question, we measured the localization of Hsp70 inhibitors using …

Proteasome inhibitor (PI) resistance remains a central challenge in multiple myeloma. To
identify pathways mediating resistance, we first mapped proteasome-associated genetic co …