Accurately reconstructing the large-scale gene order in an ancestral genome is a critical
step to better understand genome evolution. In this paper, we propose a heuristic algorithm …

Background Despite evidence for adaptive changes in both gene expression and non-
protein-coding, putatively regulatory regions of the genome during human evolution, the …

Abstract Background Tandemly Arrayed Gene (TAG) clusters are groups of paralogous
genes that are found adjacent on a chromosome. TAGs represent an important repertoire of …

The purpose of this chapter is to provide a comprehensive review of the field of genome
rearrangement, ie, comparative genomics, based on the representation of genomes as …

Gene duplication is frequent within gene clusters and plays a fundamental role in evolution
by providing a source of new genetic material upon which natural selection can act …

Clusters of genes that have evolved by repeated segmental duplication present difficult
challenges throughout genomic analysis, from sequence assembly to functional analysis …

Much important evolutionary activity occurs in gene clusters, where a copy of a gene may be
free to acquire new functions. Current computational methods to extract evolutionary …

Background Gene clusters are genetically important, but their analysis poses significant
computational challenges. One of the major reasons for these difficulties is gene conversion …

Segmental duplications are abundant in the human genome, but their evolutionary history is
not well-understood. The mystery surrounding them is due in part to their complex …

Background Segmental duplications, or low-copy repeats, are common in mammalian
genomes. In the human genome, most segmental duplications are mosaics comprised of …