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Inhibition of RNA-binding proteins with small molecules
P Wu - Nature Reviews Chemistry, 2020 - nature.com
Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …
dysregulated, can lead to a range of human diseases. The identification of small molecules …
Targeting RNA with small molecules
The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …
Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …
Synthesis, characterization, crystal structure, DNA and HSA Interactions, and anticancer activity of a mononuclear Cu (II) complex with a Schiff base ligand containing …
A mononuclear Cu (II) complex [Cu (HL)(o-phen)]· H2O (1)[H3L=, o-phen= 1, 10-
phenanthroline] was isolated from methanol, and its X-ray single-crystal structure was …
phenanthroline] was isolated from methanol, and its X-ray single-crystal structure was …
Chemo-and biosensing applications of spiropyran and its derivatives-A review
Spiropyrans are a class of photochromic compounds that feature two main isoforms, a
closed spiropyran (SP) and an open merocyanine (MC), which are inter-switchable with UV …
closed spiropyran (SP) and an open merocyanine (MC), which are inter-switchable with UV …
Interaction of copper (II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA-and albumin-binding
Copper (II) complexes with the non-steroidal anti-inflammatory drugs (NSAIDs) naproxen
and diclofenac have been synthesized and characterized in the presence of nitrogen donor …
and diclofenac have been synthesized and characterized in the presence of nitrogen donor …
Biological evaluation of non-steroidal anti-inflammatory drugs-cobalt (II) complexes
F Dimiza, AN Papadopoulos, V Tangoulis… - Dalton …, 2010 - pubs.rsc.org
Cobalt (II) complexes with the non-steroidal anti-inflammatory drug mefenamic acid in the
presence or absence of nitrogen donor heterocyclic ligands (2, 2′-bipyridine, 1, 10 …
presence or absence of nitrogen donor heterocyclic ligands (2, 2′-bipyridine, 1, 10 …
Triple helix formation and the antigene strategy for sequence-specific control of gene expression
D Praseuth, AL Guieysse, C Helene - Biochimica et Biophysica Acta (BBA) …, 1999 - Elsevier
Specific gene expression involves the binding of natural ligands to the DNA base pairs.
Among the compounds rationally designed for artificial regulation of gene expression …
Among the compounds rationally designed for artificial regulation of gene expression …
Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel (II) bis (thiosemicarbazone) complexes
A series of N-substituted isatin thiosemicarbazone ligands (L1–L5) and their nickel (II)
complexes [Ni (L) 2](1–5) were synthesized and characterized by elemental analyses and …
complexes [Ni (L) 2](1–5) were synthesized and characterized by elemental analyses and …
Automated synthesis of oligosaccharides as a basis for drug discovery
Carbohydrates present both potential and problems—their biological relevance has been
recognized, but problems in procuring sugars rendered them a difficult class of compounds …
recognized, but problems in procuring sugars rendered them a difficult class of compounds …