Glioblastoma (GBM) is the most aggressive primary brain cancer. These tumors exhibit high
intertumoral and intratumoral heterogeneity in neoplastic and nonneoplastic compartments …

Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is
characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic …

With limited treatment options, cachexia remains a major challenge for patients with cancer.
Characterizing the interplay between tumor cells and the immune microenvironment may …

Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for
many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients …

Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate
glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells …

Necrosis in solid tumors is commonly associated with poor prognostic but how these lesions
expand remains unclear. Studies have found that neutrophils associate with and contribute …

Pediatric high-grade gliomas (pHGGs), including hemispheric pHGGs and diffuse midline
gliomas (DMGs), harbor mutually exclusive tumor location-specific histone mutations. Using …

The longitudinal transition of phenotypes is pivotal in glioblastoma treatment resistance and
DNA methylation emerged as an important tool for classifying glioblastoma phenotypes. We …

Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as
attractive therapeutic targets in several cancer types, due to their ability to enhance tumor …

Glioma is the most common primary intracranial tumor in adults, with high incidence,
recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential …