Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023‏ - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut

B Nüse, T Holland, M Rauh, RG Gerlach, J Mattner - Gut Microbes, 2023‏ - Taylor & Francis
ABSTRACT L-arginine (L-arg) is a versatile amino acid and a central intestinal metabolite in
mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple …

Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome

S Saito, S Shahbaz, X Luo, M Osman… - Frontiers in …, 2024‏ - frontiersin.org
Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms,
defined as long COVID (LC), that may last months or years post the onset of acute disease …

Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases

Z Li, L Wang, Y Ren, Y Huang, W Liu, Z Lv, L Qian… - Cell death …, 2022‏ - nature.com
Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

[HTML][HTML] Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A …

M Tosato, R Calvani, A Picca, F Ciciarello, V Galluzzo… - Nutrients, 2022‏ - mdpi.com
Long COVID, a condition characterized by symptom and/or sign persistence following an
acute COVID-19 episode, is associated with reduced physical performance and endothelial …

Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality

JP Gygi, C Maguire, RK Patel, P Shinde… - The Journal of clinical …, 2024‏ - jci.org
BACKGROUND Patients hospitalized for COVID-19 exhibit diverse clinical outcomes, with
outcomes for some individuals diverging over time even though their initial disease severity …

l-Arginine and COVID-19: An Update

A Adebayo, F Varzideh, S Wilson, J Gambardella… - Nutrients, 2021‏ - mdpi.com
l-Arginine is involved in many different biological processes and recent reports indicate that
it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the …

[HTML][HTML] Endothelial dysfunction in COVID-19: a unifying mechanism and a potential therapeutic target

P Ambrosino, IL Calcaterra, M Mosella, R Formisano… - Biomedicines, 2022‏ - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a
worldwide emergency, until the declaration of the pandemic in March 2020. SARS-CoV-2 …

A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19

V Trimarco, R Izzo, SS Jankauskas, M Fordellone… - The Journal of Clinical …, 2024‏ - jci.org
BACKGROUND Recent studies conducted in individuals who survived COVID-19 suggest
that SARS-CoV-2 infection is associated with an increased risk of dyslipidemia. However, it …

Impact of COVID 19 on erectile function

DH Adeyemi, AF Odetayo, MA Hamed… - The Aging …, 2022‏ - Taylor & Francis
Abstract Purpose: COVID-19, a novel infection, presented with several complications,
including socioeconomical and reproductive health challenges such as erectile dysfunction …