Background: Fibrosis-related diseases (FRD) include cerebral fibrosis, pulmonary fibrosis,
cardiac fibrosis, liver fibrosis, renal fibrosis, peritoneal fibrosis, etc. The effects of fibrosis can …

Background Liver fibrosis is a feature in the majority of chronic liver diseases and oxidative
stress is considered to be its main pathogenic mechanism. Antioxidants including vitamin E …

Background Alcoholic liver disease (ALD) is a significant contributor to liver damage.
However, the clinical options for the treatment of ALD are limited. Astragaloside IV (AST-IV) …

Background It has been reported that formononetin (FMN), one of the main ingredients from
famous traditional Chinese medicine “Huang-qi”(Astragalus membranaceus [Fisch] Bunge) …

Paeoniflorin has shown the obvious effect on cholestasis according to our previous
research. However, its mechanism has not been absolutely explored yet. This study aims at …

Liver disease results from a dynamic pathological process associated with cellular and
genetic alterations, which may progress stepwise to liver dysfunction. Commonly, liver …

Hepatic fibrosis is a disease of the wound-healing response following chronic liver injury,
and activated hepatic stellate cells (HSCs) play a crucial role in the progression of hepatic …

Ethnopharmacological relevance Astragalus membranaceus and Salvia miltiorrhiza have
been used for centuries in China to treat liver diseases. Previous studies have shown that …

Background Non-alcoholic steatohepatitis (NASH) can develop into cirrhosis, liver failure, or
hepatocellular carcinoma without effective treatment. However, there are currently no drugs …

Abstract β-arrestins, including β-arrestin1 and β-arrestin2, are multifunctional adaptor
proteins. β-arrestins have recently been found to play new roles in regulating intracellular …