Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions …

Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …

Cell death research was revitalized by the understanding that necrosis can occur in a highly
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

Necroptosis | New England Journal of Medicine Skip to main content The New England Journal
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …

Regulated cell death has essential functions in development and in adult tissue
homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires …

Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …