RhoA as a key regulator of innate and adaptive immunity
M Bros, K Haas, L Moll, S Grabbe - Cells, 2019 - mdpi.com
RhoA is a ubiquitously expressed cytoplasmic protein that belongs to the family of small
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …
TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …
growth, development, and behaviors by modulating protein synthesis, autophagy, and …
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due
to inadequate restraint of overactivated immune cells and is associated with a variable …
to inadequate restraint of overactivated immune cells and is associated with a variable …
Lipid nanodiscs for high-resolution NMR studies of membrane proteins
Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …
The crossroads between RAS and RHO signaling pathways in cellular transformation, motility and contraction
O Soriano, M Alcón-Pérez, M Vicente-Manzanares… - Genes, 2021 - mdpi.com
Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling
pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears …
pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears …
Maintaining proteostasis under mechanical stress
Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …
functional protein networks even under conditions that threaten protein integrity. Protection …
The ras superfamily of small gtpases in non-neoplastic cerebral diseases
L Qu, C Pan, SM He, B Lang, GD Gao… - Frontiers in molecular …, 2019 - frontiersin.org
The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …
during practically the entire process of neurodevelopment, including neurogenesis …
Optical approaches for investigating neuromodulation and G protein–coupled receptor signaling
Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …
Neurogenesis, neuronal migration, and axon guidance
A Accogli, N Addour-Boudrahem, M Srour - Handbook of clinical neurology, 2020 - Elsevier
Abstract Development of the central nervous system (CNS) is a complex, dynamic process
that involves a precisely orchestrated sequence of genetic, environmental, biochemical, and …
that involves a precisely orchestrated sequence of genetic, environmental, biochemical, and …
α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes
Basement membranes (BMs) are cell-associated extracellular matrices that support tissue
integrity, signaling, and barrier properties. Type IV collagen is critical for BM function, yet …
integrity, signaling, and barrier properties. Type IV collagen is critical for BM function, yet …