Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both
endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local …

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Insulin-like growth factor-binding proteins (IGFBPs) 1–6 bind IGFs but not insulin with high
affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

The insulin-like growth factor (IGF) signaling pathway consists of multiple IGF ligands, IGF
receptors, and IGF-binding proteins (IGFBPs). Studies in a variety of animal and cellular …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …