Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
HB Clay, S Sillivan, C Konradi - International Journal of Developmental …, 2011 - Elsevier
Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …
Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications
Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
Mitochondrial oxidative phosphorylation system (OXPHOS) deficits in schizophrenia: possible interactions with cellular processes
Mitochondria are key players in the generation and regulation of cellular bioenergetics,
producing the majority of adenosine triphosphate molecules by the oxidative …
producing the majority of adenosine triphosphate molecules by the oxidative …
Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder
B Rollins, MV Martin, PA Sequeira, EA Moon… - PloS one, 2009 - journals.plos.org
Background Mitochondria provide most of the energy for brain cells by the process of
oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative …
oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative …
Decreased brain pH and pathophysiology in schizophrenia
HJ Park, I Choi, KH Leem - International Journal of Molecular Sciences, 2021 - mdpi.com
Postmortem studies reveal that the brain pH in schizophrenia patients is lower than normal.
The exact cause of this low pH is unclear, but increased lactate levels due to abnormal …
The exact cause of this low pH is unclear, but increased lactate levels due to abnormal …
Evidence of mitochondrial dysfunction within the complex genetic etiology of schizophrenia
Genetic evidence has supported the hypothesis that schizophrenia (SZ) is a polygenic
disorder caused by the disruption in function of several or many genes. The most common …
disorder caused by the disruption in function of several or many genes. The most common …
Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations
Most cell functions are carried out by interacting factors, thus underlying the functional
importance of genetic interactions between genes, termed epistasis. Epistasis could be …
importance of genetic interactions between genes, termed epistasis. Epistasis could be …
The complex interaction of mitochondrial genetics and mitochondrial pathways in psychiatric disease
While accounting for only 2% of the body's weight, the brain utilizes up to 20% of the body's
total energy. Not surprisingly, metabolic dysfunction and energy supply-and-demand …
total energy. Not surprisingly, metabolic dysfunction and energy supply-and-demand …
Mitochondrial mutations and polymorphisms in psychiatric disorders
A Sequeira, MV Martin, B Rollins, EA Moon… - Frontiers in …, 2012 - frontiersin.org
Mitochondrial deficiencies with unknown causes have been observed in schizophrenia (SZ)
and bipolar disorder (BD) in imaging and postmortem studies. Polymorphisms and somatic …
and bipolar disorder (BD) in imaging and postmortem studies. Polymorphisms and somatic …
Novel complex interactions between mitochondrial and nuclear DNA in schizophrenia and bipolar disorder
Mitochondrial dysfunction has been associated with schizophrenia (SZ) and bipolar disorder
(BD). This review examines recent publications and novel associations between …
(BD). This review examines recent publications and novel associations between …