Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Data collected on astrocytes' physiology in the rodent have placed them as key regulators of
synaptic, neuronal, network, and cognitive functions. While these findings proved highly …

Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and
hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Astrocytes are key active elements of the brain that contribute to information processing.
They not only provide neurons with metabolic and structural support, but also regulate …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

Glial cells are now recognized as active communication partners in the central nervous
system, and this new perspective has rekindled the question of their role in pathology. In the …

In addition to being essential supporters of neuronal function, astrocytes are now recognized
as active elements in the brain. Astrocytes sense and integrate synaptic activity and …