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Interfacing data science with cell therapy manufacturing: Where we are and where we need to be
Although several cell-based therapies have received FDA approval, and others are showing
promising results, scalable, and quality-driven reproducible manufacturing of therapeutic …
promising results, scalable, and quality-driven reproducible manufacturing of therapeutic …
Analysis of structural effects of sickle cell disease on brain vasculature of mice using three-dimensional quantitative phase imaging
Significance Although the molecular origins of sickle cell disease (SCD) have been
extensively studied, the effects of SCD on the vasculature—which can influence blood …
extensively studied, the effects of SCD on the vasculature—which can influence blood …
Real-time semantic segmentation and anomaly detection of functional images for cell therapy manufacturing
Background aims Cell therapy is a promising treatment method that uses living cells to
address a variety of diseases and conditions, including cardiovascular diseases, neurologic …
address a variety of diseases and conditions, including cardiovascular diseases, neurologic …
Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids
Brain organoids provide a unique opportunity to model organ development in a system
similar to human organogenesis in vivo. Brain organoids thus hold great promise for drug …
similar to human organogenesis in vivo. Brain organoids thus hold great promise for drug …
Non-invasive label-free analysis pipeline for in situ characterization of differentiation in 3d brain organoid models
Brain organoids provide a unique opportunity to model organ development in a system
similar to human organogenesis in vivo. Brain organoids thus hold great promise for drug …
similar to human organogenesis in vivo. Brain organoids thus hold great promise for drug …
SLIM-assisted automatic cartography of cell death types and rates resulting from localized photodynamic treatment
AV Belashov, AA Zhikhoreva, AV Salova… - Journal of the Optical …, 2024 - opg.optica.org
We report a spatial light interference microscopy (SLIM)-based methodology aimed at
automatic monitoring and analysis of changes in cellular morphology within extended fields …
automatic monitoring and analysis of changes in cellular morphology within extended fields …
Label-free functional analysis of root-associated microbes with dynamic quantitative oblique back-illumination microscopy
C Filan, M Green, A Diering, MT Cicerone… - Scientific Reports, 2024 - nature.com
The increasing global demand for food, coupled with concerns about the environmental
impact of synthetic fertilizers, underscores the urgency of develo** sustainable agricultural …
impact of synthetic fertilizers, underscores the urgency of develo** sustainable agricultural …
Acetic acid enabled nuclear contrast enhancement in epi-mode quantitative phase imaging
Significance The acetowhitening effect of acetic acid (AA) enhances light scattering of cell
nuclei, an effect that has been widely leveraged to facilitate tissue inspection for (pre) …
nuclei, an effect that has been widely leveraged to facilitate tissue inspection for (pre) …
Experimental assessment of the optical transfer function for quantitative oblique back illumination microscopy (qOBM)
Quantitative oblique back illumination microscopy (qOBM) is a recently developed imaging
technique that enables 3D quantitative phase imaging (QPI) and refractive index (RI) …
technique that enables 3D quantitative phase imaging (QPI) and refractive index (RI) …
Gradient Optical Diffraction Tomography
Optical diffraction tomography (ODT) enables non-invasive information-rich 3D refractive
index (RI) reconstruction of unimpaired transparent biological and technical samples, crucial …
index (RI) reconstruction of unimpaired transparent biological and technical samples, crucial …