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Towards a youth mental health paradigm: a perspective and roadmap
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology
The human brain undergoes a prolonged period of cortical development that spans multiple
decades. During childhood and adolescence, cortical development progresses from lower …
decades. During childhood and adolescence, cortical development progresses from lower …
Environmental influences on the pace of brain development
Childhood socio-economic status (SES), a measure of the availability of material and social
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
Why and how does early adversity influence development? Toward an integrated model of dimensions of environmental experience
Two extant frameworks–the harshness-unpredictability model and the threat-deprivation
model–attempt to explain which dimensions of adversity have distinct influences on …
model–attempt to explain which dimensions of adversity have distinct influences on …
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth
Animal studies of neurodevelopment have shown that recordings of intrinsic cortical activity
evolve from synchronized and high amplitude to sparse and low amplitude as plasticity …
evolve from synchronized and high amplitude to sparse and low amplitude as plasticity …
Stress and adolescence: vulnerability and opportunity during a sensitive window of development
Adolescence is a period of dynamic change across multiple systems. Concurrent maturation
of neural, biological, and psychosocial functioning renders adolescence a time of …
of neural, biological, and psychosocial functioning renders adolescence a time of …
Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans
Restoration of human brain function after injury is a signal challenge for translational
neuroscience. Rodent stroke recovery studies identify an optimal or sensitive period for …
neuroscience. Rodent stroke recovery studies identify an optimal or sensitive period for …
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Early adversity and critical periods: neurodevelopmental consequences of violating the expectable environment
It is now widely recognized that children exposed to adverse life events in the first years of
life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As …
life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As …
Neuronal ensembles: Building blocks of neural circuits
Neuronal ensembles, defined as groups of neurons displaying recurring patterns of
coordinated activity, represent an intermediate functional level between individual neurons …
coordinated activity, represent an intermediate functional level between individual neurons …