Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

L Feng, C Li, L Liu, Z Wang, Z Chen, J Yu, W Ji… - ACS …, 2022 - ACS Publications
Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy
(PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy …

Nanostructured particles assembled from natural building blocks for advanced therapies

Y Ju, H Liao, JJ Richardson, J Guo… - Chemical Society …, 2022 - pubs.rsc.org
Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …

Mo2C‐Derived Polyoxometalate for NIR‐II Photoacoustic Imaging‐Guided Chemodynamic/Photothermal Synergistic Therapy

G Liu, J Zhu, H Guo, A Sun, P Chen, L **… - Angewandte Chemie …, 2019 - Wiley Online Library
To overcome the current limitations of chemodynamic therapy (CDT), a Mo2C‐derived
polyoxometalate (POM) is readily synthesized as a new CDT agent. It permits synergistic …

Unimolecular Photodynamic O2-Economizer To Overcome Hypoxia Resistance in Phototherapeutics

M Li, Y Shao, JH Kim, Z Pu, X Zhao… - Journal of the …, 2020 - ACS Publications
Tumor hypoxia has proven to be the major bottleneck of photodynamic therapy (PDT) to
clinical transformation. Different from traditional O2 delivery approaches, here we describe …

Responsive and biocompatible chitosan-phytate microparticles with various morphology for antibacterial activity based on gas-shearing microfluidics

Q Qu, A Yang, J Wang, M **e, X Zhang… - Journal of Colloid and …, 2023 - Elsevier
Chitosan microparticles are frequently used for the encapsulation of ingredients, owing to
their pH-responsive, renewable, biocompatible and antimicrobial properties. Herein, pH …

[HTML][HTML] Recent advances in innovative strategies for enhanced cancer photodynamic therapy

T Hu, Z Wang, W Shen, R Liang, D Yan, M Wei - Theranostics, 2021 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT), a non-invasive therapeutic modality, has received increasing
attention owing to its high selectivity and limited side effects. Although significant clinical …

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and …

J Wang, J Sun, W Hu, Y Wang, T Chou… - Advanced …, 2020 - Wiley Online Library
In treatment of hypoxic tumors, oxygen‐dependent photodynamic therapy (PDT) is
considerably limited. Herein, a new bimetallic and biphasic Rh‐based core–shell …

Recent advances in the development of near-infrared organic photothermal agents

L Li, X Han, M Wang, C Li, T Jia, X Zhao - Chemical Engineering Journal, 2021 - Elsevier
Abstract Recently, near-infrared (NIR) absorbing photothermal therapy (PTT) agents, which
usually apply for deep-tissue cancer treatment, has gained increasing attention due to deep …