Targeting DNA damage response pathways in cancer
FJ Groelly, M Fawkes, RA Dagg, AN Blackford… - Nature Reviews …, 2023 - nature.com
Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …
PARP inhibitor resistance: the underlying mechanisms and clinical implications
Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
Integrative clinical genomics of advanced prostate cancer
Toward development of a precision medicine framework for metastatic, castration-resistant
prostate cancer (mCRPC), we established a multi-institutional clinical sequencing …
prostate cancer (mCRPC), we established a multi-institutional clinical sequencing …
DNA repair dysregulation from cancer driver to therapeutic target
NJ Curtin - Nature Reviews Cancer, 2012 - nature.com
Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …
DNA damage response (DDR), is associated with a predisposition to cancer and affects …
[HTML][HTML] ATM and ATR as therapeutic targets in cancer
AM Weber, AJ Ryan - Pharmacology & therapeutics, 2015 - Elsevier
In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
JHL Fok, A Ramos-Montoya… - Nature …, 2019 - nature.com
DNA-dependent protein kinase (DNA-PK) is a critical player in the DNA damage response
(DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect …
(DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect …
ATM mutations in cancer: therapeutic implications
Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …
[HTML][HTML] RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer
ABSTRACT Background BRCA1 and BRCA2 (BRCA1/2)-deficient tumors display impaired
homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents …
homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents …
The poly (ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
Background Poly (ADP-ribose) polymerase (PARP) is implicated in DNA repair and
transcription regulation. Niraparib (MK4827) is an oral potent, selective PARP-1 and PARP …
transcription regulation. Niraparib (MK4827) is an oral potent, selective PARP-1 and PARP …
Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next‐generation sequencing with a 25‐gene panel
N Tung, C Battelli, B Allen, R Kaldate, S Bhatnagar… - Cancer, 2015 - Wiley Online Library
BACKGROUND Next‐generation sequencing (NGS) allows for simultaneous sequencing of
multiple cancer susceptibility genes and, for an individual, may be more efficient and less …
multiple cancer susceptibility genes and, for an individual, may be more efficient and less …