Public health strategies aimed at disease prevention or early detection and intervention
have the potential to advance human health worldwide. However, their success depends on …

Initial expectations for genome-wide association studies were high, as such studies
promised to rapidly transform personalized medicine with individualized disease risk …

Background BRCA1 or BRCA2-mutated breast cancers are sensitive to poly (ADP-ribose)
polymerase (PARP) inhibitors and platinum agents owing to deficiency in homologous …

Importance Potentially harmful mutations of the breast cancer susceptibility 1 and 2 genes
(BRCA1/2) are associated with increased risk for breast, ovarian, fallopian tube, and …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been
reported in single populations, with the majority of reports focused on White in Europe and …

Objective: To update and examine national temporal trends in contralateral prophylactic
mastectomy (CPM) and determine whether survival differed for invasive breast cancer …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context …

Breast cancer is the most common malignancy in women with 6.6% of cases diagnosed in
young women below the age of 40. Despite variances in risk factors, Age Standardized …

An exposé on Big Pharma and the American healthcare system's zeal for excessive medical
testing, from a nationally recognized expert More screening doesn't lead to better health …