Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …

Brain aging leads to a decline in cognitive function and a concomitant increase in the
susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases …

DNA damage is a major risk factor for the decline of neuronal functions with age and in
neurodegenerative diseases. While how DNA damage causes neurodegeneration is still …

In a recent study published in Cell, Ganz et al. shed new light on the mutational landscape of
brain cells, particularly neurons and oligodendrocytes (OLs). 1 Utilizing a combination of …

Somatic mosaic variants, and especially somatic single nucleotide variants (sSNVs), occur
in progenitor cells in the develo** human brain frequently enough to provide permanent …

Recent studies demonstrate growing roles for genetic mosaicism in neurodevelopmental
and neuropsychiatric disorders, with the paradigm being drug-resistant pediatric focal …

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) resets the
aging clock. However, primed iPSCs can retain cell-of-origin epigenomic marks, especially …

Somatic mosaic variants, and especially somatic single nucleotide variants (sSNVs), occur
in progenitor cells in the develo** human brain frequently enough to provide permanent …

В условиях моделирования этанолиндуцированной энцефалопатии изучали
психофармакологические эффекты стимулятора функций прогениторных клеток …