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[HTML][HTML] Alcoholism: a systems approach from molecular physiology to addictive behavior
Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …
associated with the production, sale, and use of alcoholic beverages come at an enormous …
Molecular mechanisms underlying alcohol-drinking behaviours
The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …
alcohol despite the negative consequences. The transition from the moderate use of alcohol …
Synaptic effects induced by alcohol
DM Lovinger, M Roberto - 2023 - Springer
Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …
Drosophila melanogaster as a model to study drug addiction
Animal studies have been instrumental in providing knowledge about the molecular and
neural mechanisms underlying drug addiction. Recently, the fruit fly Drosophila …
neural mechanisms underlying drug addiction. Recently, the fruit fly Drosophila …
Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2
To investigate the potential role of alcohol use disorder (AUD) in aging processes, we
employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in …
employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in …
Invertebrate models of drug abuse
Susceptibility to drug addiction depends on genetic and environmental factors and their
complex interactions. Studies with mammalian models have identified molecular targets …
complex interactions. Studies with mammalian models have identified molecular targets …
High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila
Understanding how ethanol influences behavior is key to deciphering the mechanisms of
ethanol action and alcoholism. In mammals, low doses of ethanol stimulate locomotion …
ethanol action and alcoholism. In mammals, low doses of ethanol stimulate locomotion …
Alcohol‐related genes: contributions from studies with genetically engineered mice
Since 1996, nearly 100 genes have been studied for their effects related to ethanol in mice
using genetic modifications including gene deletion, gene overexpression, gene knock‐in …
using genetic modifications including gene deletion, gene overexpression, gene knock‐in …
Regulation of drug-taking and-seeking behaviors by neuroadaptations in the mesolimbic dopamine system
DW Self - Neuropharmacology, 2004 - Elsevier
Previous studies have identified several neuroadaptations to chronic drug use, but relatively
few have been functionally linked to addiction-related changes in drug-taking and-seeking …
few have been functionally linked to addiction-related changes in drug-taking and-seeking …
Alcohol related changes in regulation of NMDA receptor functions
Long-term alcohol exposure may lead to development of alcohol dependence in
consequence of altered neurotransmitter functions. Accumulating evidence suggests that the …
consequence of altered neurotransmitter functions. Accumulating evidence suggests that the …