Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Abstract Monoamine oxidase A (MAO A) and heat shock protein 90 (HSP90) inhibitors have
been shown to decrease the progression of glioblastoma (GBM) and other cancers. In this …

An increasing number of studies indicate that adrenergic signalling plays a fundamental role
in chronic stress-induced tumour progression and metastasis. However, its function in …

Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the
immunosuppressive tumor microenvironment and improve cancer immunotherapy …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …