Simple indolizidine and quinolizidine alkaloids

JP Michael - The alkaloids: Chemistry and biology, 2016 - Elsevier
This review of simple indolizidine and quinolizidine alkaloids (ie, those in which the parent
bicyclic systems are in general not embedded in polycyclic arrays) is an update of the …

Discovery of pamiparib (BGB-290), a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor in clinical development

H Wang, B Ren, Y Liu, B Jiang, Y Guo… - Journal of Medicinal …, 2020 - ACS Publications
Poly (ADP-ribose) polymerase (PARP) plays a significant role in DNA repair responses;
therefore, this enzyme is targeted by PARP inhibitors in cancer therapy. Here we have …

Stereoselective strategies for the construction of polysubstituted piperidinic compounds and their applications in natural products' synthesis

N Kandepedu, I Abrunhosa-Thomas… - Organic Chemistry …, 2017 - pubs.rsc.org
Nitrogen-encompassing bioactive molecules can be regarded as the most frequently cited
moieties, occurring either as natural products or as synthetically constructed chemical …

[BOOK][B] Efficiency in natural product total synthesis

HNC Wong - 2018 - books.google.com
Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this
book clearly overviews synthetic strategies and tactics applied in total synthesis …

Diastereoselective pyrrolidine synthesis via copper promoted intramolecular aminooxygenation of alkenes: formal synthesis of (+)-monomorine

MC Paderes, SR Chemler - Organic letters, 2009 - ACS Publications
The diastereoselectivity of the copper-promoted intramolecular aminooxygenation of various
alkene substrates was investigated. α-Substituted 4-pentenyl sulfonamides favor the …

Dehydrative Mannich-type reaction for the synthesis of azepinobisindole alkaloid iheyamine A

T Abe, K Yamada - Organic letters, 2018 - ACS Publications
A concise synthesis of the azepinobisindole alkaloid iheyamine A from an indole-2, 3-
epoxide equivalent has been achieved. This method features a formal C3 electrophilic …

Synthesis of Six-Membered N-Heterocycles Using Ruthenium Catalysts

N Kaur - Catalysis Letters, 2019 - Springer
A wide variety of biological activities are possessed by nitrogen, oxygen, and sulfur
containing heterocycles and many methods are explored for the preparation of these …

Highly enantioselective construction of fluoroalkylated quaternary stereocenters via organocatalytic dehydrated Mannich reaction of unprotected hemiaminals with …

S Zhang, L Li, Y Hu, Y Li, Y Yang, Z Zha, Z Wang - Organic letters, 2015 - ACS Publications
A general organocatalytic asymmetric dehydrated Mannich reaction of fluoroalkyl
hemiaminals with ketones is reported. In this Mannich reaction, previously less explored aryl …

Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (±)-crispine A

I Coldham, S Jana, L Watson, NG Martin - Organic & Biomolecular …, 2009 - pubs.rsc.org
A general approach for the synthesis of various nitrogen-containing heterocyclic compounds
is described using an intermolecular dipolar cycloaddition reaction of azomethine ylides and …

Concise Synthesis of Pyrrolidine and Indolizidine Alkaloids by a Highly Convergent Three‐Component Reaction

G Lapointe, K Schenk, P Renaud - Chemistry–A European …, 2011 - Wiley Online Library
The synthesis of pyrrolidine and indolizidine derivatives through radical carboazidation of
alkenes with α‐iodoketones, followed by reductive amination, is described. When properly …