Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination
Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR)
sequences are found in a large number of individual mice and humans. These widely …
sequences are found in a large number of individual mice and humans. These widely …
The individual and population genetics of antibody immunity
Antibodies (Abs) produced by immunoglobulin (IG) genes are the most diverse proteins
expressed in humans. While part of this diversity is generated by recombination during B …
expressed in humans. While part of this diversity is generated by recombination during B …
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
A novel framework for characterizing genomic haplotype diversity in the human immunoglobulin heavy chain locus
An incomplete ascertainment of genetic variation within the highly polymorphic
immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors …
immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors …
Population variability in the generation and selection of T-cell repertoires
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two
intrinsically stochastic steps: random receptor generation by VDJ recombination, and …
intrinsically stochastic steps: random receptor generation by VDJ recombination, and …
Individualized VDJ recombination predisposes the available Ig sequence space
The process of recombination between variable (V), diversity (D), and joining (J)
immunoglobulin (Ig) gene segments determines an individual's naive Ig repertoire and …
immunoglobulin (Ig) gene segments determines an individual's naive Ig repertoire and …
Inferred allelic variants of immunoglobulin receptor genes: a system for their evaluation, documentation, and naming
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are
encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which …
encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which …
Beyond hot spots: biases in antibody somatic hypermutation and implications for vaccine design
The evolution of antibodies in an individual during an immune response by somatic
hypermutation (SHM) is essential for the ability of the immune system to recognize and …
hypermutation (SHM) is essential for the ability of the immune system to recognize and …
Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations
Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG
variable, diversity and joining genes of the IG heavy (IGH), kappa (IGK) and lambda (IGL) …
variable, diversity and joining genes of the IG heavy (IGH), kappa (IGK) and lambda (IGL) …
Comment on “a database of human immune receptor alleles recovered from population sequencing data”
It was with great interest that we read the recently published article by Yu et al.(1), which
proposes a solution to the problem of building complete and accurate databases of germline …
proposes a solution to the problem of building complete and accurate databases of germline …