Management of diabetic foot ulcers

K Alexiadou, J Doupis - Diabetes Therapy, 2012 - Springer
Diabetic foot is a serious complication of diabetes which aggravates the patient's condition
whilst also having significant socioeconomic impact. The aim of the present review is to …

Advances in surgical applications of growth factors for wound healing

S Yamakawa, K Hayashida - Burns & trauma, 2019 - academic.oup.com
Growth factors have recently gained clinical importance for wound management. Application
of recombinant growth factors has been shown to mimic cell migration, proliferation, and …

[HTML][HTML] Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair

P Ahangar, SJ Mills, AJ Cowin - International journal of molecular …, 2020 - mdpi.com
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is
currently of enormous interest. However, the broad translation of cell therapies into clinical …

[HTML][HTML] Biofilms in diabetic foot ulcers: impact, risk factors and control strategies

AC Afonso, D Oliveira, MJ Saavedra, A Borges… - International journal of …, 2021 - mdpi.com
Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge
economic, social and psychological impact on the patients' life. One of the main reasons why …

Topical gel-based biomaterials for the treatment of diabetic foot ulcers

JR Bardill, MR Laughter, M Stager, KW Liechty… - Acta biomaterialia, 2022 - Elsevier
Diabetic foot ulcers (DFUs) are a devastating ailment for many diabetic patients with
increasing prevalence and morbidity. The complex pathophysiology of DFU wound …

Managing diabetic foot ulcers: pharmacotherapy for wound healing

D Dixon, M Edmonds - Drugs, 2021 - Springer
Historically, there has been a scarcity of evidence-based topical therapy to hasten the
healing of diabetic foot ulcers. But recently new evidence-based treatments have emerged …

Contribution of platelets, the coagulation and fibrinolytic systems to cutaneous wound healing

A Opneja, S Kapoor, EX Stavrou - Thrombosis research, 2019 - Elsevier
Wound healing is a complex process that consists of multiple phases, each of which are
indispensable for adequate repair. Timely initiation and resolution of each of these phases …

Acellular and cellular approaches to improve diabetic wound healing

H Cho, MR Blatchley, EJ Duh, S Gerecht - Advanced drug delivery reviews, 2019 - Elsevier
Chronic diabetic wounds represent a huge socioeconomic burden for both affected
individuals and the entire healthcare system. Although the number of available treatment …

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

J Ishihara, A Ishihara, K Fukunaga, K Sasaki… - Nature …, 2018 - nature.com
Laminin, as a key component of the basement membrane extracellular matrix (ECM),
regulates tissue morphogenesis. Here, we show that multiple laminin isoforms …

[HTML][HTML] Epithelial mechanobiology, skin wound healing, and the stem cell niche

ND Evans, ROC Oreffo, E Healy, PJ Thurner… - Journal of the mechanical …, 2013 - Elsevier
Skin wound healing is a vital process that is important for re-establishing the epithelial
barrier following disease or injury. Aberrant or delayed skin wound healing increases the …