Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Overview and recent advances in the treatment of neuroblastoma
SB Whittle, V Smith, E Doherty, S Zhao… - Expert review of …, 2017 - Taylor & Francis
Introduction: Children with neuroblastoma have widely divergent outcomes, ranging from
cure in> 90% of patients with low risk disease to< 50% for those with high risk disease …
cure in> 90% of patients with low risk disease to< 50% for those with high risk disease …
Neuroblastoma—a neural crest derived embryonal malignancy
Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …
The genetic landscape of high-risk neuroblastoma
Neuroblastoma is a malignancy of the develo** sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …
Recent advances in neuroblastoma
JM Maris - New England Journal of Medicine, 2010 - Mass Medical Soc
Neuroblastoma, an embryonal cancer of the autonomic nervous system, is the most common
cancer diagnosed during the first year of life. Although neuroblastoma accounts for …
cancer diagnosed during the first year of life. Although neuroblastoma accounts for …
Neuroblastoma: paradigm for precision medicine
MS Irwin, JR Park - Pediatric Clinics, 2015 - pediatric.theclinics.com
Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is
derived from the develo** sympathetic nervous system. Clinical phenotypes range from …
derived from the develo** sympathetic nervous system. Clinical phenotypes range from …
Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers
S Rousseaux, A Debernardi, B Jacquiau… - Science translational …, 2013 - science.org
Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are
the unexplored consequences of malignant epigenetic reprogramming. We designed a …
the unexplored consequences of malignant epigenetic reprogramming. We designed a …
Whole-genome resequencing of 292 pigeonpea accessions identifies genomic regions associated with domestication and agronomic traits
Pigeonpea (Cajanus cajan), a tropical grain legume with low input requirements, is
expected to continue to have an important role in supplying food and nutritional security in …
expected to continue to have an important role in supplying food and nutritional security in …
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nature, 2010 - nature.com
Copy number variants (CNVs) account for a major proportion of human genetic
polymorphism and have been predicted to have an important role in genetic susceptibility to …
polymorphism and have been predicted to have an important role in genetic susceptibility to …