Regulated cell death pathways in doxorubicin-induced cardiotoxicity

E Christidi, LR Brunham - Cell Death & Disease, 2021 - nature.com
Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

[HTML][HTML] Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.

A Romani, F Ieri, S Urciuoli, A Noce, G Marrone… - Nutrients, 2019 - mdpi.com
Olea europaea L. fruit is a peculiar vegetal matrix containing high levels of fatty acids (98–
99% of the total weight of extra-virgin olive oil, EVOO) and low quantities (1–2%) of …

Nrf2: a dark horse in doxorubicin-induced cardiotoxicity

X Zhao, Z Tian, M Sun, D Dong - Cell death discovery, 2023 - nature.com
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

[HTML][HTML] Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

C Nediani, J Ruzzolini, A Romani, L Calorini - Antioxidants, 2019 - mdpi.com
Growing scientific literature data suggest that the intake of natural bioactive compounds
plays a critical role in preventing or reducing the occurrence of human chronic non …

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

N Koleini, E Kardami - Oncotarget, 2017 - pmc.ncbi.nlm.nih.gov
Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy
protocols. Severe side effects such as cardiotoxicity, however, limit Dox application …

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

S Bulotta, M Celano, SM Lepore, T Montalcini… - Journal of translational …, 2014 - Springer
The overall health beneficial action of olive oil phenolic components is well established.
Recent studies have elucidated the biological effects of two isolated compounds, namely …

Olive tree (Olea europaea L.) leaf as a waste by‐product of table olive and olive oil industry: a review

S Şahin, M Bilgin - Journal of the Science of Food and …, 2018 - Wiley Online Library
Research into finding new uses for by‐products of table olive and olive oil industry are of
great value not only to the economy but also to the environment where olives are grown and …

Nutraceutical properties of olive oil polyphenols. An itinerary from cultured cells through animal models to humans

S Rigacci, M Stefani - International journal of molecular sciences, 2016 - mdpi.com
The increasing interest in the Mediterranean diet hinges on its healthy and anti-ageing
properties. The composition of fatty acids, vitamins and polyphenols in olive oil, a key …

[HTML][HTML] Mitochondria and doxorubicin-induced cardiomyopathy: a complex interplay

L Schirone, L D'Ambrosio, M Forte, R Genovese… - Cells, 2022 - mdpi.com
Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting
nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer …

The role of AMPK activation for cardioprotection in doxorubicin-induced cardiotoxicity

KN Timm, DJ Tyler - Cardiovascular drugs and therapy, 2020 - Springer
Doxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of
cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic …