Introduction to radiobiology of targeted radionuclide therapy

JP Pouget, C Lozza, E Deshayes, V Boudousq… - Frontiers in …, 2015 - frontiersin.org
During the last decades, new radionuclide-based targeted therapies have emerged as
efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a …

Review of computational anthropomorphic anatomical and physiological models

H Zaidi, BMW Tsui - Proceedings of the IEEE, 2009 - ieeexplore.ieee.org
The widespread availability of high-performance computing and accurate and realistic
computer simulation techniques has stimulated the development of computational …

Intratumorally injected 177Lu-labeled gold nanoparticles: gold nanoseed brachytherapy with application for neoadjuvant treatment of locally advanced breast cancer

S Yook, Z Cai, Y Lu, MA Winnik… - Journal of Nuclear …, 2016 - jnm.snmjournals.org
Improvements in the treatment of locally advanced breast cancer (LABC) are needed. Our
objective was to study a radiation nanomedicine (gold nanoseeds) composed of 30-nm gold …

111In-labeled trastuzumab-modified gold nanoparticles are cytotoxic in vitro to HER2-positive breast cancer cells and arrest tumor growth in vivo in athymic mice after …

Z Cai, N Chattopadhyay, K Yang, YL Kwon… - Nuclear medicine and …, 2016 - Elsevier
Abstract Introduction Gold nanoparticles (AuNP; 30 nm) were modified with polyethylene
glycol (PEG) chains linked to trastuzumab for binding to HER2-positive breast cancer (BC) …

Treatment of orthotopic U251 human glioblastoma multiforme tumors in NRG mice by convection-enhanced delivery of gold nanoparticles labeled with the β-particle …

CJ Georgiou, Z Cai, N Alsaden, H Cho… - Molecular …, 2022 - ACS Publications
In this study, we investigated convection-enhanced delivery (CED) of 23±3 nm gold
nanoparticles (AuNPs) labeled with the β-particle-emitting radionuclide 177Lu (177Lu …

Adjuvant Auger Electron-Emitting Radioimmunotherapy with [111In]In-DOTA-Panitumumab in a Mouse Model of Local Recurrence and Metastatic Progression of …

VJ Facca, Z Cai, A Ku, CJ Georgiou… - Molecular …, 2023 - ACS Publications
Triple-negative breast cancer (TNBC) has a high risk for recurrence and metastasis. We
studied the effectiveness of Auger electron (AE) radioimmunotherapy (RIT) with …

Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy

L Martinez-Vidal, C Testi, E Pontecorvo, F Pederzoli… - Scientific Reports, 2024 - nature.com
Bladder mechanical properties are critical for organ function and tissue homeostasis.
Therefore, alterations of tissue mechanics are linked to disease onset and progression. This …

Dose assessment in environmental radiological protection: State of the art and perspectives

K Stark, JM Goméz-Ros, JV i Batlle, EL Hansen… - Journal of …, 2017 - Elsevier
Exposure to radiation is a potential hazard to humans and the environment. The Fukushima
accident reminded the world of the importance of a reliable risk management system that …

90Y-Labeled Gold Nanoparticle Depot (NPD) Combined with Anti-PD-L1 Antibodies Strongly Inhibits the Growth of 4T1 Tumors in Immunocompetent Mice and …

Z Cai, R Liu, C Chan, Y Lu, MA Winnik… - Molecular …, 2022 - ACS Publications
The effectiveness and normal tissue toxicity of a novel nanoparticle depot (NPD)
brachytherapy seed incorporating gold nanoparticles (AuNPs) labeled with β-particle …

Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand

S Boschi, JT Lee, S Beykan, R Slavik, L Wei… - European journal of …, 2016 - Springer
Purpose The aim of this study was to synthesize and preclinically evaluate an 18 F-PSMA
positron emission tomography (PET) tracer. Prostate-specific membrane antigen (PSMA) …