Clinical application of advanced multi-omics tumor profiling: Sha** precision oncology of the future
D Akhoundova, MA Rubin - Cancer Cell, 2022 - cell.com
Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …
through the identification of therapeutic targets and molecular biomarkers, leading to the …
Insights into the role of sialylation in cancer progression and metastasis
Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
INTRODUCTION Dendritic cells (DCs) and monocytes consist of multiple specialized
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …
Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy
CX Dominguez, S Müller, S Keerthivasan, H Koeppen… - Cancer discovery, 2020 - AACR
With only a fraction of patients responding to cancer immunotherapy, a better understanding
of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart …
of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart …
Single-cell analyses identify brain mural cells expressing CD19 as potential off-tumor targets for CAR-T immunotherapies
CD19-directed immunotherapies are clinically effective for treating B cell malignancies but
also cause a high incidence of neurotoxicity. A subset of patients treated with chimeric …
also cause a high incidence of neurotoxicity. A subset of patients treated with chimeric …
Molecular features of cancer-associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance
Abstract Purpose: Cancer-associated fibroblasts (CAFs) are an important component of the
tumor microenvironment, but a systematic investigation of their molecular characteristics and …
tumor microenvironment, but a systematic investigation of their molecular characteristics and …
Pan-cancer proteogenomics expands the landscape of therapeutic targets
Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug
Administration (FDA). We integrate Clinical Proteomic Tumor Analysis Consortium (CPTAC) …
Administration (FDA). We integrate Clinical Proteomic Tumor Analysis Consortium (CPTAC) …
Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
A pragmatic guide to enrichment strategies for mass spectrometry–based glycoproteomics
Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …
implications in molecular biology. This heterogeneity precludes enrichment strategies that …