Functional brain connectivity changes across the human life span: From fetal development to old age

M Edde, G Leroux, E Altena… - Journal of Neuroscience …, 2021 - Wiley Online Library
The dynamic of the temporal correlations between brain areas, called functional connectivity
(FC), undergoes complex transformations through the life span. In this review, we aim to …

Dynamic graph metrics: Tutorial, toolbox, and tale

AE Sizemore, DS Bassett - NeuroImage, 2018 - Elsevier
The central nervous system is composed of many individual units–from cells to areas–that
are connected with one another in a complex pattern of functional interactions that supports …

Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects

MP Harms, LH Somerville, BM Ances, J Andersson… - Neuroimage, 2018 - Elsevier
Abstract The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are
two large-scale brain imaging studies that will extend the recently completed HCP Young …

Common variants contribute to intrinsic human brain functional networks

B Zhao, T Li, SM Smith, D **ong, X Wang, Y Yang… - Nature Genetics, 2022 - nature.com
The human brain forms functional networks of correlated activity, which have been linked
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …

[HTML][HTML] When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging

R Pedersen, L Geerligs, M Andersson, T Gorbach… - Neuroimage, 2021 - Elsevier
Healthy aging is accompanied by progressive decline in cognitive performance and
concomitant changes in brain structure and functional architecture. Age-accompanied …

Structure-function coupling in white matter uncovers the abnormal brain connectivity in schizophrenia

J Zhao, CC Huang, Y Zhang, Y Liu, SJ Tsai… - Translational …, 2023 - nature.com
Schizophrenia is characterized by dysconnectivity syndrome. Evidence of widespread
impairment of structural and functional integration has been demonstrated in schizophrenia …

Resting-state networks in the course of aging—differential insights from studies across the lifespan vs. amongst the old

C Jockwitz, S Caspers - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
Resting-state functional connectivity (RSFC) has widely been used to examine
reorganization of functional brain networks during normal aging. The extraction of …

Functional connectome through the human life span

L Sun, T Zhao, X Liang, M **a, Q Li, X Liao, G Gong… - Biorxiv, 2024 - pmc.ncbi.nlm.nih.gov
The lifespan growth of the functional connectome remains unknown. Here, we assemble
task-free functional and structural magnetic resonance imaging data from 33,250 individuals …

Age-related alterations in axonal microstructure in the corpus callosum measured by high-gradient diffusion MRI

Q Fan, Q Tian, NA Ohringer, A Nummenmaa, T Witzel… - Neuroimage, 2019 - Elsevier
Cerebral white matter exhibits age-related degenerative changes during the course of
normal aging, including decreases in axon density and alterations in axonal structure …

Structure–Function Interactions in the Hippocampus and Prefrontal Cortex Are Associated with Episodic Memory in Healthy Aging

J Snytte, R Setton, L Mwilambwe-Tshilobo, MN Rajah… - Eneuro, 2024 - eneuro.org
Aging comes with declines in episodic memory. Memory decline is accompanied by
structural and functional alterations within key brain regions, including the hippocampus and …