Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

In nature, living organisms evolve unique functional components with mechanically adaptive
compatibility to cater dynamic change of interface friction/lubrication. This mechanism can …

The major synovial joints such as hips and knees are uniquely efficient tribological systems,
able to articulate over a wide range of shear rates with a friction coefficient between the …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

Osteoarthritis is the most common degenerative and highly prevalent joint disease,
characterized by progressive loss and destruction of articular cartilage. The damaged …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …