Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Key determinants of success in fecal microbiota transplantation: From microbiome to clinic

S Porcari, N Benech, M Valles-Colomer, N Segata… - Cell host & …, 2023 - cell.com
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …

[HTML][HTML] Influence of foods and nutrition on the gut microbiome and implications for intestinal health

P Zhang - International journal of molecular sciences, 2022 - mdpi.com
Food components in our diet provide not only necessary nutrients to our body but also
substrates for the mutualistic microbial flora in our gastrointestinal tract, termed the gut …

Treatment of inflammatory bowel disease: a comprehensive review

Z Cai, S Wang, J Li - Frontiers in medicine, 2021 - frontiersin.org
Inflammatory bowel disease (IBD), as a global disease, has attracted much research
interest. Constant research has led to a better understanding of the disease condition and …

Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis

L Jia, Y Jiang, L Wu, J Fu, J Du, Z Luo, L Guo… - Nature …, 2024 - nature.com
Periodontitis is closely related to inflammatory bowel disease (IBD). An excessive and non-
self-limiting immune response to the dysbiotic microbiome characterizes the two. However …

STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD …

D Turner, A Ricciuto, A Lewis, F D'amico, J Dhaliwal… - Gastroenterology, 2021 - Elsevier
Background The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE)
initiative of the International Organization for the Study of Inflammatory Bowel Diseases …

Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy

C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

EN Baruch, I Youngster, G Ben-Betzalel, R Ortenberg… - Science, 2021 - science.org
The gut microbiome has been shown to influence the response of tumors to anti–PD-1
(programmed cell death–1) immunotherapy in preclinical mouse models and observational …

Newer biologic and small-molecule therapies for inflammatory bowel disease

DC Baumgart, C Le Berre - New England Journal of Medicine, 2021 - Mass Medical Soc
Newer Biologic and Small-Molecule Therapies for IBD There is still no cure for inflammatory
bowel disease. This review covers newer treatments that reflect our understanding of the …