There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Abstract These European Resuscitation Council (ERC) Cardiac Arrest in Special
Circumstances guidelines are based on the 2020 International Consensus on …

The “sepsis bundle” has been central to the implementation of the Surviving Sepsis
Campaign (SSC) from the first publication of its evidence-based guidelines in 2004 through …

BACKGROUND: Prospective, single-center trials have shown that the implementation of the
Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Importance Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis.
Endotoxin activity can be measured in blood with a rapid assay. Treating patients with septic …

Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.
Objectives: To evaluate the association between antibiotic timing and mortality among …