Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Objective: Imaging studies of major depressive disorder have reported structural and
functional abnormalities in a variety of spatially diverse brain regions. Quantitative meta …

MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble
administration, has been applied for focal temporary BBB opening in patients with …

Parkinson's disease (PD) is a neurodegenerative pathology, the origin of which is
associated with the death of neuronal cells involved in the production of dopamine. The …

It has been well established that neuronal loss within the cholinergic nucleus basalis of
Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's …

Accurate differential diagnosis of parkinsonism is of paramount therapeutic and prognostic
importance. In addition, with the development of invasive therapies and novel disease …

Abstract See Gratwicke and Foltynie (doi: 10.1093/brain/awx333) for a scientific commentary
on this article. Cognitive impairments are a prevalent and disabling non-motor complication …

Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-
associated neurodegenerative pathologies, together determining an individual's course of …

Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's
disease. Around 30% of patients with Parkinson's disease experience mild cognitive …