Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …

An antibody's stability greatly influences its performance (ie its specificity and affinity). Thus,
stability is a major issue for researchers and manufacturers, especially with the increasing …

This study tests the impact of drone transportation on the quality of a medicine. Modelling the
critical process parameters of drone flight, the effects of temperature and vibration on insulin …

Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

The dependence of the localized surface plasmon resonance (LSPR) of noble-metal
nanomaterials on refractive index makes LSPR a useful, label-free signal transduction …

In antibody development and manufacturing, protein aggregation is a common challenge
that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to …

Stability studies under stress conditions or forced degradation studies play an important role
in different phases of development and production of biopharmaceuticals and biological …

Purpose This study addresses the effect of freezing and thawing on a therapeutic
monoclonal antibody (mAb) solution and the corresponding buffer formulation. Particle …

The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …

This study was designed to assess the effects of cooling rate, storage temperature, and
formulation composition on trehalose phase distribution and protein stability in frozen …