The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …

INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …

Blood formation is believed to occur through stepwise progression of haematopoietic stem
cells (HSCs) following a tree-like hierarchy of oligo-, bi-and unipotent progenitors. However …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Chromosomal rearrangements without gene fusions have been implicated in
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …