Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …

BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …

Annulus fibrosus (AF) defect is an important cause of disc re-herniation after discectomy.
The self-regeneration ability of the AF is limited, and AF repair is always hindered by the …

Lumbar discectomy is the surgical procedure most frequently performed for patients
suffering from low back pain and sciatica. Disc herniation as a consequence of degenerative …

Tissue-engineered approaches for the treatment of early-stage intervertebral disc
degeneration have shown promise in preclinical studies. However, none of these therapies …

Intervertebral disc degeneration is a well-known cause of disability, the result of which
includes neck and back pain with associated mobility limitations. The purpose of this article …

There is currently a lack of clinically available solutions to restore functionality to the
intervertebral disk (IVD) following herniation injury to the annulus fibrosus (AF) …

Objective Intervertebral disk degeneration is a prevalent postoperative complication after
discectomy, underscoring the need to develop preventative and bioactive treatment …

Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are
associated with painful conditions and accelerated intervertebral disc (IVD) degeneration …

Low back pain resulting from disc degeneration is a leading cause of disability worldwide.
However, to date few therapies target the cause and fail to repair the intervertebral disc …