Single-cell pathogen diagnostics for combating antibiotic resistance

H Li, K Hsieh, PK Wong, KE Mach, JC Liao… - Nature Reviews …, 2023 - nature.com
Bacterial infections and antimicrobial resistance are a major cause for morbidity and
mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where …

Point-of-care nucleic acid tests: assays and devices

OI Wilner, D Yesodi, Y Weizmann - Nanoscale, 2023 - pubs.rsc.org
The COVID-19 pandemic (caused by the SARS_CoV_2 virus) has emphasized the need for
quick, easy-to-operate, reliable, and affordable diagnostic tests and devices at the Point-of …

Point-of-care CRISPR-Cas-assisted SARS-CoV-2 detection in an automated and portable droplet magnetofluidic device

FE Chen, PW Lee, AY Trick, JS Park, L Chen… - Biosensors and …, 2021 - Elsevier
In the fight against COVID-19, there remains an unmet need for point-of-care (POC)
diagnostic testing tools that can rapidly and sensitively detect the causative SARS-CoV-2 …

Translating diagnostics and drug delivery technologies to low-resource settings

EM Euliano, AA Sklavounos, AR Wheeler… - Science translational …, 2022 - science.org
Diagnostics and drug delivery technologies engineered for low-resource settings aim to
meet their technical design specifications using strategies that are compatible with limited …

From saliva to SNP: non-invasive, point-of-care genoty** for precision medicine applications using recombinase polymerase amplification and giant …

AS de Olazarra, DL Cortade, SX Wang - Lab on a Chip, 2022 - pubs.rsc.org
Genetic testing is considered a cornerstone of the precision medicine paradigm. Genoty**
of single nucleotide polymorphisms (SNPs) has been shown to provide insights into several …

Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

K Hsieh, JH Melendez, CA Gaydos, TH Wang - Lab on a Chip, 2022 - pubs.rsc.org
The incidence rates of sexually transmitted infections (STIs), including the four major curable
STIs–chlamydia, gonorrhea, trichomoniasis and, syphilis–continue to increase globally …

Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects

D Golparian, M Unemo - Expert Review of Molecular Diagnostics, 2022 - Taylor & Francis
Introduction Several nucleic acid amplification tests (NAATs), mostly PCRs, to detect
antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae are …

Magnetofluidic immuno-PCR for point-of-care COVID-19 serological testing

P Zhang, L Chen, J Hu, AY Trick, FE Chen… - Biosensors and …, 2022 - Elsevier
Serological tests play an important role in the fight against Coronavirus Disease 2019
(COVID-19), including monitoring the dynamic immune response after vaccination …

Nucleic Acid Amplification‐Based Technologies (NAAT)—Toward Accessible, Autonomous, and Mobile Diagnostics

V Narasimhan, H Kim, SH Lee, H Kang… - Advanced Materials …, 2023 - Wiley Online Library
The ongoing pandemic and increasing frequency of infectious disease outbreaks due to
climate change, urbanization, and global human migration have put great focus on nucleic …

Sensitive and quantitative point-of-care HIV viral load quantification from blood using a power-free plasma separation and portable magnetofluidic polymerase chain …

HT Ngo, M **, AY Trick, FE Chen, L Chen… - Analytical …, 2022 - ACS Publications
Point-of-care (POC) HIV viral load (VL) tests are needed to enhance access to HIV VL
testing in low-and middle-income countries (LMICs) and to enable HIV VL self-testing at …