Alternatives to gadolinium-based metal chelates for magnetic resonance imaging
Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical
imaging over the last few decades owing to its exceptional spatial and anatomical …
imaging over the last few decades owing to its exceptional spatial and anatomical …
Divalent Manganese Complexes as Potential Replacements for Gadolinium-Based Contrast Agents
P Caravan - Investigative Radiology, 2023 - journals.lww.com
Recent safety concerns surrounding the use of gadolinium-based contrast agents (GBCAs)
have spurred research into identifying alternatives to GBCAs for use with magnetic …
have spurred research into identifying alternatives to GBCAs for use with magnetic …
Comparative paraCEST effect of amide and hydroxy groups in divalent cobalt and nickel complexes of tripyridine-based ligands
Co (II) and Ni (II) complexes of two tri-pyridine-based ligands with two hydroxy and two
amide exchangeable protons (TDTA) and with six amide exchangeable protons (TMTP) …
amide exchangeable protons (TDTA) and with six amide exchangeable protons (TMTP) …
High relaxivity magnetic resonance imaging contrast agents part 1: impact of single donor atom substitution on relaxivity of serum albumin-bound gadolinium …
S Dumas, V Jacques, WC Sun, JS Troughton… - Investigative …, 2010 - journals.lww.com
Rationale and Objectives: The donor atoms that bind to gadolinium in contrast agents
influence inner-sphere water exchange and electronic relaxation, both of which determine …
influence inner-sphere water exchange and electronic relaxation, both of which determine …
Fe (II) and Co (II) N-methylated CYCLEN complexes as paraSHIFT agents with large temperature dependent shifts
Several complexes of Co (II) or Fe (II) with 1, 4, 7, 10-tetraazacyclododecane (CYCLEN)
appended with 1, 7-(6-methyl) 2-picolyl groups are studied as 1H NMR paraSHIFT agents …
appended with 1, 7-(6-methyl) 2-picolyl groups are studied as 1H NMR paraSHIFT agents …
Stability and toxicity of contrast agents
The chapter on stability and toxicity of contrast agents gives an update of thermodynamic
and kinetic constants for new metal ion—ligand complexes that are explored as a potential …
and kinetic constants for new metal ion—ligand complexes that are explored as a potential …
Transition metal Parashift and ParaCEST MRI agents: Current progress and challenges
The development of ParaCEST and Parashift agents presents opportunities for MRI
molecular imaging agents (rather than simple contrast agents) for map** physiological …
molecular imaging agents (rather than simple contrast agents) for map** physiological …
Optimising the relaxivities of Mn 2+ complexes by targeting human serum albumin (HSA)
We report two novel macrocyclic ligands based on the 1, 4-DO2AM platform (1, 4-DO2AM=
2, 2′-(1, 4, 7, 10-tetraazacyclododecane-1, 4-diyl) diacetamide) and containing two benzyl …
2, 2′-(1, 4, 7, 10-tetraazacyclododecane-1, 4-diyl) diacetamide) and containing two benzyl …
[HTML][HTML] Imparting multivalency to a bifunctional chelator: a scaffold design for targeted PET imaging probes
W Liu, G Hao, MA Long, T Anthony… - … (International ed. in …, 2009 - ncbi.nlm.nih.gov
Positron Emission Tomography (PET) has become a standard clinical practice in the
diagnostic or prognostic imaging of cancer mainly due to the great success of [18F] FDG (2 …
diagnostic or prognostic imaging of cancer mainly due to the great success of [18F] FDG (2 …
Inert macrocyclic Eu 3+ complex with affirmative paraCEST features
T Gambino, L Valencia, P Pérez-Lourido… - Inorganic Chemistry …, 2020 - pubs.rsc.org
We report on a macrocyclic platform based on an 18-membered macrocycle that forms
kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the …
kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the …