Tackling the challenge created by antibiotic resistance requires understanding the
mechanisms behind its evolution. Like any evolutionary process, the evolution of …

Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …

Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within …

Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …

Filamentous bacteriophage (Pf phage) contribute to the virulence of Pseudomonas
aeruginosa infections in animal models, but their relevance to human disease is unclear. We …

Introduction: Bronchiectasis is a chronic endobronchial suppurative disease characterized
by irreversibly dilated bronchi damaged by repeated polymicrobial infections and …

Pseudomonas aeruginosa biofilms cause chronic, antibiotic tolerant infections in wounds
and lungs. Numerous recent studies demonstrate that bacteria can detect human …

Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial
genomic changes. Recent large-scale genomic data from prolonged infections allow the …

Background Pseudomonas aeruginosa is a multidrug-resistant pathogen causing
recalcitrant pulmonary infections in people with cystic fibrosis (pwCF). Cystic fibrosis …

During infections, bacterial pathogens can engage in a variety of interactions with each
other, ranging from the cooperative sharing of resources to deadly warfare. This is especially …