Pharmacotherapeutics applications and chemistry of chalcone derivatives
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …
Chalcone: a promising bioactive scaffold in medicinal chemistry
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Exploring pharmacological significance of chalcone scaffold: a review
NK Sahu, SS Balbhadra… - Current medicinal …, 2012 - ingentaconnect.com
Chalcones (1, 3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the
flavonoid family, which possess a number of interesting biological properties such as …
flavonoid family, which possess a number of interesting biological properties such as …
Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review
Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …
Recent developments of coumarin-containing derivatives and their anti-tubercular activity
YQ Hu, Z Xu, S Zhang, X Wu, JW Ding, ZS Lv… - European journal of …, 2017 - Elsevier
Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused
predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs …
predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs …
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline
and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity …
and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity …
1, 2, 3-Triazole tethered β-lactam-chalcone bifunctional hybrids: synthesis and anticancer evaluation
The manuscript describes the synthesis of novel 1, 2, 3-triazole tethered β-lactam-chalcone
bifunctional hybrids via click chemistry approach utilizing azide-alkyne cycloaddition …
bifunctional hybrids via click chemistry approach utilizing azide-alkyne cycloaddition …
QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity
New anti-tuberculosis (anti-TB) drugs are urgently needed to battle drug-resistant
Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment …
Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment …
1, 2, 3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226
Abstract A new series of 1, 2, 3-triazole-chalcone hybrids has been synthesized and
screened in vitro against a panel of 60 human cancer cell lines according to NCI (USA) …
screened in vitro against a panel of 60 human cancer cell lines according to NCI (USA) …
Antimicrobial and in-silico evaluation of novel chalcone and amide-linked 1, 4-disubstituted 1, 2, 3 triazoles
MK Sharma, S Parashar, M Chahal, K Lal… - Journal of Molecular …, 2022 - Elsevier
Abstract Design, synthesis, spectral characterization and antimicrobial evaluation of a series
of twelve chalcone-containing amide linked 1, 4-disubstituted 1, 2, 3-triazole hybrids and …
of twelve chalcone-containing amide linked 1, 4-disubstituted 1, 2, 3-triazole hybrids and …