Cryptochromes are blue-light receptors that mediate photoresponses in plants. The
genomes of most land plants encode two clades of cryptochromes, CRY1 and CRY2, which …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Environmental temperature cycles are a universal entraining cue for all circadian systems at
the organismal level with the exception of homeothermic vertebrates. We report here that …

Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we
show, using optogenetic manipulation and video recording, that a subset of dorsal clock …

Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

The photopigment in the human eye that transduces light for circadian and neuroendocrine
regulation, is unknown. The aim of this study was to establish an action spectrum for light …

Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where
they play key roles in growth and development. Subsequently identified in prokaryotes …

In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the
brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we …

Circadian oscillations in mammalian physiology and behavior are regulated by an
endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known …

Arabidopsis thaliana cryptochrome 2 (At CRY2), a light-sensitive photosensory protein, was
previously adapted for use in controlling protein–protein interactions through light …