The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

One of the landmark events of the past 25 years in neuroscience research was the
establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Nervous systems are composed of various cell types, but the extent of cell type diversity is
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

To understand how the brain processes sensory information to guide behavior, we must
know how stimulus representations are transformed throughout the visual cortex. Here we …

Normal aging is accompanied by escalating systemic inflammation. Yet the potential impact
of immune homeostasis on neurogenesis and cognitive decline during brain aging have not …

Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

The neocortex is the part of the brain responsible for execution of higher-order brain
functions, including cognition, sensory perception, and sophisticated motor control. During …

Significant advances in circuit-level analyses of the brain require tools that allow for labeling,
modulation of gene expression, and monitoring and manipulation of cellular activity in …