In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …

Alzheimer's disease (AD), is a progressive neurodegenerative disease that affects behavior,
thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

In Alzheimer's disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by
intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic …

Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …

Perivascular spaces (PVS) of the brain, often called Virchow-Robin spaces, comprise fluid,
cells and connective tissue, and are externally limited by astrocytic endfeet. PVS are …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …

Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the
study of dementia, considered their possible role in help defining diagnostic biomarkers of …

During wakefulness, extracellular levels of metabolites in the brain increase. These include
amyloid beta (Aβ), which contributes to the pathogenesis of Alzheimer's disease (AD) …

Abstract Study Objectives: Emerging evidence suggests a role for sleep in contributing to the
progression of Alzheimer disease (AD). Slow wave sleep (SWS) is the stage during which …