Nanotherapeutic approaches for transdermal drug delivery systems and their biomedical applications

SU Khan, M Ullah, S Saeed, EAM Saleh… - European Polymer …, 2024 - Elsevier
Transdermal drug delivery systems (TDDS) are designed to deliver drugs through the skin
and into the systemic circulation. They offer several advantages over traditional oral or …

Beyond the beat: a pioneering investigation into exercise modalities for alleviating diabetic cardiomyopathy and enhancing cardiac health

AR Khan, MAH Alnoud, H Ali, I Ali, S Ahmad… - Current Problems in …, 2024 - Elsevier
Patients with preexisting cardiovascular disease or those at high risk for develo** the
condition are often offered exercise as a form of therapy. Patients with cancer who are at an …

Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

L Pang, S Guo, F Khan, M Dunterman, H Ali, Y Liu… - Cell Reports …, 2023 - cell.com
Glioblastoma (GBM) is a hypoxic and" immune-cold" tumor containing rich stromal signaling
molecules and cell populations, such as proteases and immunosuppressive tumor …

Triple coumarin-based 5-fluorouracil prodrugs, their synthesis, characterization, and release kinetics

YF Mustafa - Journal of Molecular Structure, 2024 - Elsevier
Fluorouracil (5-FU) has been commonly used as a chemotherapy medication in cancer
management. However, owing to its substantial side effects, limited selectivity, and tumor …

[HTML][HTML] Data-independent acquisition mass spectrometry analysis of FFPE rectal cancer samples offers in-depth proteomics characterization of the response to …

A Stanojevic, M Samiotaki, V Lygirou… - International Journal of …, 2023 - mdpi.com
Locally advanced rectal cancer (LARC) presents a challenge in identifying molecular
markers linked to the response to neoadjuvant chemoradiotherapy (nCRT). This study …

Comprehensive overview of utilizing metal-organic frameworks (MOFs) for precise cancer drug delivery

MU Khan, M Alissa, M Inam, MA Alsuwat… - Microchemical …, 2024 - Elsevier
Cancer is a complex disease that develops due to complex interactions between hereditary
and environmental variables. This devastating disease has far-reaching consequences for …

Cardiomegaly: Navigating the uncharted territories of heart failure-A multimodal radiological journey through advanced imaging, pathophysiological landscapes, and …

MK Iqbal, A Ambreen, M Mujahid, Y Zarlasht… - Current Problems in …, 2024 - Elsevier
Cardiomegaly is among the disorders categorized by a structural enlargement of the heart
by any of the situations including pregnancy, resulting in damage to heart muscles and …

[HTML][HTML] Cancer cell secreted legumain promotes gastric cancer resistance to anti-PD-1 immunotherapy by enhancing macrophage M2 polarization

X Pei, SL Zhang, BQ Qiu, PF Zhang, TS Liu, Y Wang - Pharmaceuticals, 2024 - mdpi.com
The interaction between cancer cells and immune cells plays critical roles in gastric cancer
(GC) progression and immune evasion. Forced legumain (LGMN) is one of the …

Heartfelt living: Deciphering the link between lifestyle choices and cardiovascular vitality

X Jiang, MAH Alnoud, H Ali, I Ali, T Hussain… - Current Problems in …, 2024 - Elsevier
Cardiovascular diseases (CVDs) are still leading to a significant number of deaths
worldwide despite the remarkable advancements in medical technology and pharmacology …

Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis

Q Fan, S Wen, Y Zhang, X Feng, W Zheng, X Liang… - Iscience, 2024 - cell.com
The causality between circulating proteins and thyroid cancer (TC) remains unclear. We
employed five large-scale circulating proteomic genome-wide association studies (GWASs) …