Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives

R Sun, J **ang, Q Zhou, Y Piao, J Tang, S Shao… - Advanced Drug Delivery …, 2022 - Elsevier
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …

Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

The ancillary effects of nanoparticles and their implications for nanomedicine

EP Stater, AY Sonay, C Hart, J Grimm - Nature Nanotechnology, 2021 - nature.com
Nanoparticles are often engineered as a scaffolding system to combine targeting, imaging
and/or therapeutic moieties into a unitary agent. However, mostly overlooked, the …

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

N Hasan, A Nadaf, M Imran, U Jiba, A Sheikh… - Molecular cancer, 2023 - Springer
Skin cancer is a global threat to the healthcare system and is estimated to incline
tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is …

Advances in nanomaterial-mediated photothermal cancer therapies: toward clinical applications

HS Han, KY Choi - Biomedicines, 2021 - mdpi.com
Photothermal therapy (PTT) has attracted extensive research attention as a noninvasive and
selective treatment strategy for numerous cancers. PTT functions via photothermal effects …

Engineering tumoral vascular leakiness with gold nanoparticles

MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga… - Nature …, 2023 - nature.com
Delivering cancer therapeutics to tumors necessitates their escape from the surrounding
blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer …

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Y Liu, P Bhattarai, Z Dai, X Chen - Chemical Society Reviews, 2019 - pubs.rsc.org
The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound
energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and …

Noncancerous disease-targeting AIEgens

Y Duo, G Luo, W Zhang, R Wang, GG **ao… - Chemical Society …, 2023 - pubs.rsc.org
Noncancerous diseases include a wide plethora of medical conditions beyond cancer and
are a major cause of mortality around the world. Despite progresses in clinical research …