Adipose-tissue plasticity in health and disease
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
Muscle–organ crosstalk: the emerging roles of myokines
MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …
[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
Local hyperthermia therapy induces browning of white fat and treats obesity
Y Li, D Wang, X **, Y Zhang, T Zhang, L Wang, L **… - Cell, 2022 - cell.com
Beige fat plays key roles in the regulation of systemic energy homeostasis; however,
detailed mechanisms and safe strategy for its activation remain elusive. In this study, we …
detailed mechanisms and safe strategy for its activation remain elusive. In this study, we …
[HTML][HTML] Human brown adipocyte thermogenesis is driven by β2-AR stimulation
Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 …
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 …
The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
AE O'Mara, JW Johnson, JD Linderman… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …
Brown adipose tissue—a translational perspective
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
B Niemann, S Haufs-Brusberg, L Puetz, M Feickert… - Nature, 2022 - nature.com
Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …
Brown adipose tissue as a secretory organ
Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and experimental
studies have associated BAT activity with protection against obesity and metabolic diseases …
studies have associated BAT activity with protection against obesity and metabolic diseases …