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Vaccination in patients with kidney failure: lessons from COVID-19
Infection is the second leading cause of death in patients with chronic kidney disease (CKD).
Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize …
Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize …
Immunosuppressive agents and infectious risk in transplantation: managing the “net state of immunosuppression”
MB Roberts, JA Fishman - Clinical Infectious Diseases, 2021 - academic.oup.com
Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …
[HTML][HTML] Weak antibody response to three doses of mRNA vaccine in kidney transplant recipients treated with belatacept
Poor responses to mRNA COVID-19 vaccine have been reported after 2 vaccine injections
in kidney transplant recipients (KTRs) treated with belatacept. We analyzed the humoral …
in kidney transplant recipients (KTRs) treated with belatacept. We analyzed the humoral …
Translating B cell immunology to the treatment of antibody-mediated allograft rejection
PS Heeger, MC Haro, S Jordan - Nature Reviews Nephrology, 2024 - nature.com
Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in
diagnosis for decades. However, the immunological mechanism underlying their generation …
diagnosis for decades. However, the immunological mechanism underlying their generation …
[HTML][HTML] Immunosuppressive drugs modes of action
The innate and adaptive immune systems work as a complex interplay between different cell
types, involving cytokines and chemokines mediating extracellular and paracrine effects. At …
types, involving cytokines and chemokines mediating extracellular and paracrine effects. At …
Immunogenicity and reactogenicity after SARS-CoV-2 mRNA vaccination in kidney transplant recipients taking belatacept
Background. Belatacept may impair humoral immunity, impacting the effectiveness of SARS-
CoV-2 mRNA vaccines in transplant recipients. We investigated immunogenicity after SARS …
CoV-2 mRNA vaccines in transplant recipients. We investigated immunogenicity after SARS …
The calcineurin inhibitor tacrolimus specifically suppresses human T follicular helper cells
Background T follicular helper (Tfh) cells are key players in the production of antibody-
producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells …
producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells …
IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic
kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this …
kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this …
[HTML][HTML] Dual targeting: combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients
CK Burghuber, M Manook, B Ezekian, AC Gibby… - American Journal of …, 2019 - Elsevier
Previous evidence suggests that a homeostatic germinal center (GC) response may limit
bortezomib desensitization therapy. We evaluated the combination of costimulation …
bortezomib desensitization therapy. We evaluated the combination of costimulation …