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Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
[HTML][HTML] Intrinsically disordered proteins: an overview
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Abstract AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can
visualize, analyze and interpret the structures and functions of all proteins solely from their …
visualize, analyze and interpret the structures and functions of all proteins solely from their …
AlphaFold, artificial intelligence (AI), and allostery
AlphaFold has burst into our lives. A powerful algorithm that underscores the strength of
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …
AlphaFold2 fails to predict protein fold switching
AlphaFold2 has revolutionized protein structure prediction by leveraging sequence
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
[HTML][HTML] AlphaFold2: a role for disordered protein/region prediction?
The development of AlphaFold2 marked a paradigm-shift in the structural biology
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
A hairpin motif in the amyloid-β peptide is important for formation of disease-related oligomers
The amyloid-β (Aβ) peptide is associated with the development of Alzheimer's disease and
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …
AlphaFold 2 and NMR spectroscopy: partners to understand protein structure, dynamics and function
DV Laurents - Frontiers in molecular biosciences, 2022 - frontiersin.org
The artificial intelligence program AlphaFold 2 is revolutionizing the field of protein structure
determination as it accurately predicts the 3D structure of two thirds of the human proteome …
determination as it accurately predicts the 3D structure of two thirds of the human proteome …
Predicting protein flexibility with AlphaFold
AlphaFold2 has revolutionized protein structure prediction from amino‐acid sequence. In
addition to protein structures, high‐resolution dynamics information about various protein …
addition to protein structures, high‐resolution dynamics information about various protein …
Impact of nanoplastics on Alzheimer's disease: Enhanced amyloid-β peptide aggregation and augmented neurotoxicity
X Gou, Y Fu, J Li, J **ang, M Yang, Y Zhang - Journal of Hazardous …, 2024 - Elsevier
Nanoplastics, widely existing in the environment and organisms, have been proven to cross
the blood-brain barrier, increasing the incidence of neurodegenerative diseases like …
the blood-brain barrier, increasing the incidence of neurodegenerative diseases like …