Mechanisms and pathology of protein misfolding and aggregation

N Louros, J Schymkowitz, F Rousseau - Nature Reviews Molecular Cell …, 2023 - nature.com
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

[HTML][HTML] Intrinsically disordered proteins: an overview

R Trivedi, HA Nagarajaram - International journal of molecular sciences, 2022 - mdpi.com
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

AlphaFold2 models indicate that protein sequence determines both structure and dynamics

HB Guo, A Perminov, S Bekele, G Kedziora… - Scientific reports, 2022 - nature.com
Abstract AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can
visualize, analyze and interpret the structures and functions of all proteins solely from their …

AlphaFold, artificial intelligence (AI), and allostery

R Nussinov, M Zhang, Y Liu, H Jang - The Journal of Physical …, 2022 - ACS Publications
AlphaFold has burst into our lives. A powerful algorithm that underscores the strength of
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …

AlphaFold2 fails to predict protein fold switching

D Chakravarty, LL Porter - Protein Science, 2022 - Wiley Online Library
AlphaFold2 has revolutionized protein structure prediction by leveraging sequence
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …

[HTML][HTML] AlphaFold2: a role for disordered protein/region prediction?

CJ Wilson, WY Choy, M Karttunen - International Journal of Molecular …, 2022 - mdpi.com
The development of AlphaFold2 marked a paradigm-shift in the structural biology
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …

A hairpin motif in the amyloid-β peptide is important for formation of disease-related oligomers

M Khaled, I Rönnbäck, LL Ilag… - Journal of the …, 2023 - ACS Publications
The amyloid-β (Aβ) peptide is associated with the development of Alzheimer's disease and
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …

AlphaFold 2 and NMR spectroscopy: partners to understand protein structure, dynamics and function

DV Laurents - Frontiers in molecular biosciences, 2022 - frontiersin.org
The artificial intelligence program AlphaFold 2 is revolutionizing the field of protein structure
determination as it accurately predicts the 3D structure of two thirds of the human proteome …

Predicting protein flexibility with AlphaFold

P Ma, DW Li, R Brüschweiler - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
AlphaFold2 has revolutionized protein structure prediction from amino‐acid sequence. In
addition to protein structures, high‐resolution dynamics information about various protein …

Impact of nanoplastics on Alzheimer's disease: Enhanced amyloid-β peptide aggregation and augmented neurotoxicity

X Gou, Y Fu, J Li, J **ang, M Yang, Y Zhang - Journal of Hazardous …, 2024 - Elsevier
Nanoplastics, widely existing in the environment and organisms, have been proven to cross
the blood-brain barrier, increasing the incidence of neurodegenerative diseases like …